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Examination of postoperative outcomes following elective colorectal surgery
(2023)
for an elective colectomy procedure between January 1, 2016, to December 31, 2021. Patient demographics, ERAS protocol adherence, surgery-level characteristics (e.g., surgical approach, procedure type, etc.), and health-system level characteristics (e...
A Method for Identification of Pancreatic Cancer through Methylation Signatures in Cell-Free DNA
(2022)
Pancreatic cancer has high mortality rates in comparison to other cancers due to limited treatment options and challenges in detecting the disease. Early diagnosis is difficult; successful outcomes are directly tied to ...
Bugs, Drugs and Data: Antibiotic Resistance, Prevalence and Prediction of Bug-Drug Mismatch using Electronic Health Records (EHR) Data
(2021)
Bug-Drug Mismatch (BDM) occurrences are an important and modifiable category of inappropriate antibiotic therapy (IAAT) that increases adverse outcomes for patients and drives overall antibiotic resistance (AR). Surveillance ...
Discovery of Peptide and Aptamer Ligands for Targeted Drug Delivery to Hepatic Stellate Cells
(University of Missouri--Kansas City, 2016)
The objective of this dissertation is to present two approaches to identify Hepatic
Stellate Cells (HSCs) targeting ligands using phage-display library biopanning and
systematic evolution of ligands by exponential ...